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KMID : 1007520110200041133
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Food Science and Biotechnology
2011 Volume.20 No. 4 p.1133 ~ p.1136
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Effects of α-Lipoic Acid Supplementation on Malondialdehyde Contents and Superoxide Dismutase in Rat Skeletal Muscles
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Kim Wan-Jae
Kang Jun-yong
Kwon Dae-Keun
Song Young-Ju
Lee Kwang-Ho
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Abstract
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This study investigated the effects of α-lipoic acid (ALA) supplementation on the malondialdehyde (MDA) contents and superoxide dismutase (SOD) protein expression in rat skeletal muscles under non-exercising condition. Fourteen Sprague-Dawley male rats at the age of 6 weeks were randomly divided into 2 groups CS, (normal diet group, n=7) and AS (0.5% ALA supplemented diet group, n=7), and keep non-exercising condition for 4 weeks. The muscle MDA concentration of the AS group was significantly lower than that of the CS group in the both soleus and extensor digitorum longus muscles. The expressions of Cu/Zn-SOD and Mn-SOD proteins in the soleus muscle were significantly higher in the AS group than that in the CS group. From these results, ALA supplementation under non-exercising condition had a role in increasing of antioxidant enzymes in skeletal muscle types of rats.
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KEYWORD
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α-lipoic acid, malondialdehyde, superoxide dismutase, skeletal muscle
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